THIONE DERIVATIVES, PROCESSES FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

摘要

PURPOSE: A thione derivative, a processes for preparing the same, and a pharmaceutical composition containing the same are provided, which compound has fever removing, pain alleviating and anti-inflammatory effects. CONSTITUTION: A thione derivative is represented by the formula(1), wherein A and B are independently O, S, NR2; R2 is hydrogen, C1-C4 alkyl, C1-C4 alkenyl, or aryl; Ar is aryl, heteroaryl, or aryl or heteroaryl substituted 1 to 5 substituents selected from C1-C4 alkyl, C1-C4 alkoxy, halogen, trifluoromethyl, nitro, acetoxy, amine, C1-C3 alkyl amine, C1-C3 dialkylamine, hydroxy, C1-C3 hydroxy alkyl and thioxy; and R1 is hydrogen, C1-C4 alkyl, C1-C4 alkoxy, halogen, cyano, nitro, hydroxy, amino, C1-C4 alkylamino or di-C1-C4 alkylamino. a method for preparing the thione derivative of the formula(1) or nontoxic salts thereof comprises reacting propionic acid derivative of the formula(2) with phosphorus pentasulfide, Lawesson's reagent, beta-oxothionic acid or beta-oxothionic acid potassium salt, wherein R3 is C1-C4 alkyl.