发明名称 |
Multi-state genetic oscillator |
摘要 |
Provided are methods and compositions for regulating gene expression in a cell. The invention provides recombinant multi-state genetic oscillators containing an adjustable-threshold genetic switch that is periodically activated by an oscillating amount of an activator agent. The activating agent is a gene product expressed from a promoter regulated by the adjustable-threshold switch and thus forms a feedback loop that causes periodic switching of the adjustable-threshold switch between an "on" state and an "off" state. Multi-state genetic oscillators are useful to express one or more genes of interest in a periodic manner without requiring a periodic application of an external activating agent.
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申请公布号 |
US6737269(B2) |
申请公布日期 |
2004.05.18 |
申请号 |
US20010872338 |
申请日期 |
2001.06.01 |
申请人 |
BOSTON UNIVERSITY |
发明人 |
GARDNER TIMOTHY;COLLINS JAMES J. |
分类号 |
C12N1/11;C12N1/19;C12N15/63;(IPC1-7):C12N15/09;C12N15/00;C12N15/86;C12Q1/68;C07H21/04 |
主分类号 |
C12N1/11 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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