| 发明名称 |
Overcoming DAPA aminotransferase bottlenecks in biotin vitamers biosynthesis |
| 摘要 |
A method is disclosed for the increased production of biotin and the biotin precursor dethiobiotin using a bacterium that produces a lysine-utilizing DAPA aminotransferase. This method involves the use of a bacterium that is either grown in the presence of lysine or deregulated for lysine biosynthesis.
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| 申请公布号 |
US6737256(B2) |
申请公布日期 |
2004.05.18 |
| 申请号 |
US19970914332 |
申请日期 |
1997.07.14 |
| 申请人 |
ROCHE VITAMINS INC. |
发明人 |
VAN ARSDELL SCOTT W.;YOCUM R. ROGERS;PERKINS JOHN B.;PERO JANICE G. |
| 分类号 |
C12N9/10;C07D233/32;C07D495/04;C12N1/20;C12N1/21;C12P13/00;C12P17/18;C12R1/125;C12R1/19;C12R1/43;(IPC1-7):C12P17/18;C12N15/00 |
主分类号 |
C12N9/10 |
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