发明名称 |
Method for detecting protein inhibitors and ligands of medical value |
摘要 |
The invention relates to a method for detecting inhibitors or ligands of binding domains, which comprises using a protein which contains at least one catalytic domain and at least one binding domain, incubating said protein with a marker substrate which binds to the catalytic domain of the protein and is converted, with a substrate which can reversibly bind to the catalytic domain and to the binding domain, and with the inhibitor and determining whether the marker substrate is converted by the protein.
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申请公布号 |
US6737246(B2) |
申请公布日期 |
2004.05.18 |
申请号 |
US20010876091 |
申请日期 |
2001.06.08 |
申请人 |
AVENTIS PHARMA DEUTSCHLAND, GMBH |
发明人 |
WEITHMANN KLAUS-ULRICH |
分类号 |
A61K31/44;A61K31/702;A61K38/00;A61P1/02;A61P1/04;A61P1/14;A61P9/10;A61P17/02;A61P19/02;A61P25/00;A61P25/04;A61P27/00;A61P29/00;A61P31/04;A61P35/00;A61P35/04;A61P37/02;A61P43/00;C07D211/70;C12Q1/37;(IPC1-7):C12Q1/34 |
主分类号 |
A61K31/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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