| 摘要 |
Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates, enantiomers, and diastereomers, and prodrugs thereof, are useful as inhibitors of LFA-1/ICAM and as anti-inflammatory agents, wherein L and K are O or S; Z is N or CR<SUB>4b</SUB>; Ar is an optionally-substituted aryl or heteroaryl; G is a linker attached to T or M or is absent; J, M and T are selected to define a three to six membered saturated or partially unsaturated non-aromatic ring; and R<SUB>2</SUB>,R<SUB>4a</SUB>, R<SUB>4b</SUB>, and R<SUB>4c </SUB>are as defined in the specification.
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