| 摘要 |
<p>A compound comprising a target cell specific portion and a cytotoxic portion, characterised in that the cytotoxic portion of the compound is a constitutively active caspase or has substantially the same apoptosis inducing activity as the said caspases. Alternatively, the invention provides a compound comprising a mediator portion and a cytotoxic portion, characterised in that the cytotoxic portion of the compound is a constitutively active caspase or has substantially the same apoptosis inducing activity as the said caspases. Preferably the cytotoxic portion of the compounds of the invention is a constitutively active caspase 3, caspase 6 or caspase 7. The invention further provides nucleic acids encoding the compounds of the invention, and the use of such compounds in medicine, e.g. in the treatment of cancer.</p> |
