SCREENING METHOD FOR COMPOUND ACCUMULATED AT SPECIFIC PART

摘要

PROBLEM TO BE SOLVED: To provide a method for specifically transmitting physiologically active substances to a specific internal organ in a living body, for example the spleen or the thymus. SOLUTION: A probe expressed by a following expression (I) is medicated to animals other than a human being. The probe is determined by the image measurement of the animal itself, or the spleen, organization, or cells sampled from the animal at fixed time to identify the organs, organization, or cells where a compound to be inspected is accumulated. The expression (I) is expressed by (S1-L1)m-B1-(F1)n. S1in the expression indicates a compound residue to be inspected; L1indicates an organism adaptive macromolecular residue that can position-specifically or chemically combine S1and B1via L1; F1indicates an imaging reagent residue; and B1indicates a linker that can chemically combine 1-60 Ls and 1-10 F1s via B1or 1-60 Ls, where m and n indicate 1-60 integers and 0-10 integers, respectively. COPYRIGHT: (C)2004,JPO