发明名称 |
Zebrafish huc promoter capable of directing neuron-specific expression of structural genes, transgenic animal having huc promoter and its generation, and method for screening neuronal mutant animals using the transgenic animal |
摘要 |
The present invention relates to a zebrafish HuC promoter with its 5'-flanking region which directs the neuron-specific expression of structural genes, a transgenic animal that shows the neuron-specific expression of GFP (green fluorescence protein) under the regulation of the HuC promoter, and a method for screening neurogenesis mutants in zebrafish by use of the transgenic animal. The HuC promoter with its 5'-flanking region can be used in the study of the regulatory mechanism responsible for the differentiation of the nervous system. Additionally, the HuCP-GFP transgenic zebrafish enables the direct identification of neurogenesis and axonogenesis, as well as being a valuable tool for isolating and analyzing neurogenesis mutants in live zebrafish with ease.
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申请公布号 |
US2004093630(A1) |
申请公布日期 |
2004.05.13 |
申请号 |
US20020296665 |
申请日期 |
2002.11.25 |
申请人 |
HUH TAE LIN;PARK HAEL-CHUL;KIM CHUL-HEE;KIM HYUNG-SEOK |
发明人 |
HUH TAE LIN;PARK HAEL-CHUL;KIM CHUL-HEE;KIM HYUNG-SEOK |
分类号 |
C12N15/11;A01K67/027;C07K14/46;C12N15/85;(IPC1-7):A01K67/027;C07H21/04;C12P21/02;C12N5/06 |
主分类号 |
C12N15/11 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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