METHOD FOR THE PREPARATION OF CHIRAL HYDROXY ESTERS BY ENZYME/METAL MULTI-CATALYSIS

摘要

The invention provides a process for preparing a chiral hydroxy ester by reacting a compound having botha ketone group and an acyloxy group in a molecule with a hydrogen donor which reduces the ketone group into an hydroxyl group; a metal complex, which catalyzes both the reduction of the ketone and racemization reaction of produced hydroxy group; and an enzyme, which catalyzes enantioselective acyl transfer in anorganic solvent.