METHOD OF MEASURING BINDING SITE ON PLASMA PROTEIN OF PLASMA PROTEIN-BINDING DRUG AND METHOD OF MEASURING PLASMA PROTEIN MUTATION

摘要

A method for conveniently measuring the plasma protein-binding site of a drug having a binding affinity for plasma protein and the effect of the binding substitution thereof, and application of the same to clinical diagnosis. That is to say, it is intended to provide a method which comprises reacting a first drug, the binding site of which on plasma protein is to be measured, with a second drug, the binding site of which on plasma protein is already known, and plasma protein and then measuring a change in the release ratio of the first drug due to the binding of the second drug to plasma protein to thereby measure the binding site of the first drug on the plasma protein.