发明名称 |
Substituted pyridines and pyridazines with angiogenesis inhibiting activity |
摘要 |
Substituted and pyridines and pyridazines having angiogenesis inhibiting activity and the generalized structural formula wherein the ring containing A, B, D, E, and L is phenyl or a nitrogen-containing heterocycle; groups X and Y may be any of a variety of defined linking units; R<1 >and R<2 >may be defined independent substituents or together may be a ring-defining bridge; ring J may be an aryl, pyridyl, or cycloalkyl group; and G groups may be any of a variety of defined substituents. Pharmaceutical compositions containing these materials, and methods of treating a mammal having a condition characterized by abnormal angiogenesis or hyperpermiability processes using these materials are also disclosed.
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申请公布号 |
US2004092740(A1) |
申请公布日期 |
2004.05.13 |
申请号 |
US20030720702 |
申请日期 |
2003.11.24 |
申请人 |
BAYER PHARMACEUTICALS CORPORATION |
发明人 |
DUMAS JACQUES P.;BOYER STEPHEN JAMES;DIXON JULIE A.;JOE TEDDY KITE;KLUENDER HAROLD C. E.;LEE WENDY;NAGARATHNAM DHANAPALAN;SIBLEY ROBERT N.;SU NING |
分类号 |
C07D401/06;C07D401/12;C07D401/14;C07D403/12;C07D403/14;C07D405/14;C07D417/12;C07D417/14;C07D487/04;C07D491/04;C07D495/04;C07D513/04;(IPC1-7):C07D487/02;C0743/02 |
主分类号 |
C07D401/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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