发明名称 |
SCREENING, QUANTITATION AND IDENTIFICATION OF ACTIVE INGREDIENTS IN NATURAL PRODUCTS |
摘要 |
This invention provides a method for screening a mixture of compounds for activity comprising steps of contacting the mixture with a system which mimics an organ capable of metabolizing the mixture in an appropriate time to generate a metabolite; and determining the activity of the generated metabolite. This invention also provides a method for quantitating a mixture of compounds comprising steps of contacting the mixture with a system which mimics an organ capable of metabolizing the mixture in an appropriate time to generate a metabolite; and determining the activity of the generated metabolite. This invention further provides a method for identifying an active metabolite from a mixture of compounds comprising steps of contacting the mixture with a system which mimics an organ capable of metabolizing the mixture in an appropriate time to generate a metabolite; and determining the activity of the metabolite generated. Finally, this invention provides various uses of this method and the identified metabolite. |
申请公布号 |
WO2004040259(A2) |
申请公布日期 |
2004.05.13 |
申请号 |
WO2003US33616 |
申请日期 |
2003.10.24 |
申请人 |
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH;SCHWARTZ, GARY, K. |
发明人 |
SCHWARTZ, GARY, K. |
分类号 |
C12Q1/00;G01N33/50 |
主分类号 |
C12Q1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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