BACILLUS LICHENIFORMIS MUTANT HOST CELL

摘要

A Bacillus licheniformis mutant host cell comprising a mutation ( deletion ) in one or more genes encoding contaminating native secreted polypeptides (e.g. proteolytic enzymes, nutrient uptake factors and signal molecules), wherein the mutant host cell expresses at least 5% less of the one or more proteases than the parent host cell, when cultivated under comparable conditions. The mutant host cell is used for producing heterologous polypeptides.