<p>An inhibitor-resistant HCV NS3 protease is provided which is useful to screen for compounds having therapeutic value against drug resistant HCV strains. In particular, the inhibitor-resistant HCV NS3 protease comprises an amino acid sequence which is mutated in the substrate binding pocket thereof rendering the protease resistant to inhibitor. In a specific aspect of the present invention, at least one of the amino acids at position 155, 156 and 168 of the HCV NS3 protease is mutated to yield an inhibitor-resistant protease.</p>
申请公布号
WO2004039970(A1)
申请公布日期
2004.05.13
申请号
WO2003CA01636
申请日期
2003.10.24
申请人
BOEHRINGER INGELHEIM INTERNATIONAL GMBH;KUKOLJ, GEORGE;LAGACE, LISETTE;MARQUIS, MARTIN;LAMARRE, DANIEL;PAUSE, ARNIM