发明名称 Azoles as malonyl-coa decarboxylase inhibitors useful as metabolic modulators
摘要 The present invention relates to methods of treatment of certain metabolic diseases, and to novel compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In particular, this invention relates to the use of novel compounds and compositions for treatment of cardiovascular diseases, diabetes, cancers, acidosis, and obesity through the inhibition of malonyl-CoA decarboxylase (MCD). These compounds have the formulae (I) and (II), wherein Y, C, R1, R2, R6, and R7 are defined herein.
申请公布号 US2004092503(A1) 申请公布日期 2004.05.13
申请号 US20030468379 申请日期 2003.08.19
申请人 ARRHENIUS THOMAS;CHENG JIE FEI;WILSON MARK E;SERAFIMOV ROSSY 发明人 ARRHENIUS THOMAS;CHENG JIE FEI;WILSON MARK E;SERAFIMOV ROSSY
分类号 A61K31/4745;A61K31/519;A61K31/538;A61K31/548;A61K31/55;C07D277/70;C07D417/04;C07D513/04;(IPC1-7):A61K31/55;A61K31/474 主分类号 A61K31/4745
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