| 摘要 |
PROBLEM TO BE SOLVED: To obtain a phosphoric acid or phosphonic acid derivative, pharmacologically acceptable salts or esters thereof, all having high immunosuppressive activity. SOLUTION: The phosphoric acid or phosphonic acid derivative is represented by formula(I)( wherein, R<SP>1</SP>and R<SP>2</SP>are each H, or the like; R<SP>3</SP>and Ra<SP>3</SP>are each H or a phosphate group-protecting group; R<SP>4</SP>is H, a lower alkyl, or the like; (n) is 1-6; X is ethylene group, or the like; Y is a single bond, a 1-10C alkylene group, or the like; Z is O or methylene group; R<SP>5</SP>is H, a cycloalkyl, an aryl, or the like; R<SP>6</SP>and R<SP>7</SP>are each H, a halogen atom, or the like; wherein, when R<SP>5</SP>is H, Y is a substituted 1-10C alkylene group, or the like ). The pharmacologically acceptable salts or esters of the phosphoric acid or phosphonic acid derivative are also provided, respectively. COPYRIGHT: (C)2004,JPO
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