| 发明名称 |
COMPOSITIONS AND METHODS FOR MODIFYING TOXIC EFFECTS OF PROTEINACEOUS COMPOUNDS |
| 摘要 |
The present invention provides methods to produce immunotoxins (ITs) and cytokines with a reduced ability to promote vascular leak syndrome (VLS). Th e invention also provides Its and cytokines which have been mutated to lack amino acid sequences which induce VLS.
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| 申请公布号 |
CA2503763(A1) |
申请公布日期 |
2004.05.13 |
| 申请号 |
CA20032503763 |
申请日期 |
2003.10.29 |
| 申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
VITETTA, ELLEN S.;GHETIE, VICTOR F.;SMALLSHAW, JOAN;BALUNA, ROXANA G. |
| 分类号 |
A61K38/00;A61K38/16;A61K38/19;A61K39/02;A61K39/395;C07K14/00;C07K14/415;C07K14/55;C07K16/46;C07K19/00;G01N;(IPC1-7):A61K38/00 |
主分类号 |
A61K38/00 |
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