QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF Flt3 AND MEDICINAL COMPOSITIONS CONTAINING THE SAME

摘要

It is intended to provide compounds and drugs efficacious against diseases which can be effectively treated by inhibiting autophosphorylation of FMS-like tyrosine kinase 3 (Flt3). Namely, a medicinal composition to be used in preventing or treating diseases which can be effectively treated or prevented by inhibiting autophosphorylation of Flt3, comprising a compound represented by the following general formula (I) or pharmaceutically acceptable salts thereof or solvates of the same: (I) wherein X represents CH or N; Z represents O or S; R<1>, R<2> and R<3> represent each H, OH or optionally substituted alkoxy; R<4> represents H; R<5>, R<6>, R<7> and R<8> represent each H, Hal, alkyl, etc.; and R<9> represents alkyl, etc. substituted by t-butyl, etc.