ADENOSYLMETHIONINE SYNTHETASE FROM STREPTOMYCES SP., GENE SEQUENCES CODING THE SAME AND METHOD FOR MASS PRODUCTION OF SECONDARY METABOLITES INCLUDING ANTIBIOTICS THEREOF

摘要

Disclosed is an isolated nucleotide sequence encoding an enzyme catalyzing biosynthesis of SAM (SAM-s) and its amino acid sequence. Also, the present invention provides a method for mass production of a useful secondary metabolite including antibiotics using the isolated nucleotide sequence and SAM, where SAM acts as a methyl group donor.