发明名称 |
A THREE-STEP METHOD FOR PRODUCING PACLITAXEL |
摘要 |
<p>The present invention relates to a method of producing paclitaxel from a protected coupled ester compound having a formula:wherein P1 is a hydrogenatable protecting group, comprising deprotecting the 7-O-position and 3'-N-position of the protected coupled ester compound to form a first intermediate compound, benzoylating the first intermediate compound at the 3'-N-position thereby to form a second intermediate compound, and deprotecting the second intermediate compound by replacing P1 with hydrogen in the presence of an acid. The present invention also provides chemical compounds useful in the production of paclitaxel.</p> |
申请公布号 |
IL158494(D0) |
申请公布日期 |
2004.05.12 |
申请号 |
IL20020158494 |
申请日期 |
2002.04.25 |
申请人 |
NAPRO BIOTHERAPEUTICS, INC. |
发明人 |
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分类号 |
A61K31/337;A61P35/00;B01J23/44;C07B61/00;C07D305/14;(IPC1-7):C07D |
主分类号 |
A61K31/337 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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