发明名称 |
Crystal forms of 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-4-(3-ethynyl-phenyl)-1-methyl-1H-quinolin-2-one, 2,3,- dihydroxybutanedioate salts and method of production |
摘要 |
The invention relates to crystal forms of 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-4-(3-ethynyl-phenyl)-1-methyl-1H-quinolin-2-one, 2,3-dihydroxy butanedioate salts having the formula shown below:and to pharmaceutical compositions containing the above compound, methods of treating hyperproliferative diseases, such as cancers, in mammals, especially humans by administering the above compound, and to methods of preparing the crystal forms of the above compound and related compounds.
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申请公布号 |
US6734308(B2) |
申请公布日期 |
2004.05.11 |
申请号 |
US20030441567 |
申请日期 |
2003.05.20 |
申请人 |
PFIZER INC |
发明人 |
LYSSIKATOS JOSEPH P.;TICKNER DEREK L.;NEWTON LINDA S.;LI ZHENG J.;MELTZ CLIFFORD N. |
分类号 |
A61K31/4709;A61P35/00;C07D401/06;(IPC1-7):C07D215/227 |
主分类号 |
A61K31/4709 |
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