发明名称 |
Gastrokines and derived peptides including inhibitors |
摘要 |
A novel group of gastrokines called Gastric Antrum Mucosal Protein is characterized. A member of the group is designated AMP-18. AMP-18 genomic DNA, cDNA and the AMP-18 protein are sequenced for human, mouse and pig. The AMP-18 protein and active peptides derived from it are cellular growth factors. Surprisingly, peptides capable of inhibiting the effects of the complete protein, are also derived from the AMP-18 protein. Control of mammalian gastro-intestinal tissues growth and repair is facilitated by the use of the proteins, making the proteins candidates for therapies.
|
申请公布号 |
US6734289(B2) |
申请公布日期 |
2004.05.11 |
申请号 |
US20010821726 |
申请日期 |
2001.03.29 |
申请人 |
THE UNIVERSITY OF CHICAGO |
发明人 |
MARTIN TERENCE;TOBACK F. GARY;POWELL C. THOMAS;AGARWAL KAN |
分类号 |
A01K67/027;A61K38/00;A61P1/00;A61P1/04;A61P29/00;A61P43/00;C07K14/475;C07K14/52;C07K16/22;C07K16/24;C12N5/06;C12N5/08;C12N15/09;C12N15/19;C12P21/02;(IPC1-7):A61K38/17;A61K38/04 |
主分类号 |
A01K67/027 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|