发明名称 |
Method for re-sensitizing vancomycin resistant bacteria which selectively cleave a cell wall depsipeptide |
摘要 |
The present invention relates a method for re-sensitizing vancomycin resistant Gram-positive bacteria in which resistance results from the conversion of an amide bond to an ester bond in the cell wall peptide precursors of the bacteria which comprises using an antibacterial amount of vancomycin or a homolog of vancomycin and an amount of an agent effective to selectively cleave the ester bond so as to thereby re-sensitize vancomycin resistant bacteria.
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申请公布号 |
US6734165(B2) |
申请公布日期 |
2004.05.11 |
申请号 |
US20010938746 |
申请日期 |
2001.08.23 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK;THE ROCKEFELLER UNIVERSITY |
发明人 |
CHIOSIS GABRIELA;BONECA IVO G.;STILL W. CLARK |
分类号 |
A61K31/40;A61K38/14;(IPC1-7):A61K38/16;A61K38/00 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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