| 摘要 |
The invention regards a novel use of pharmaceutical compositions in treati ng symptoms of disorders relating to neurological diseases and for treating pathophysiologicially related symptomology in other body tissues, including peripheral neuropathies, secondary symptomology of diabetes, Alzeheimer's disease, Parkinson's disease, alcoholic polyneuropathy and age-onset symptomology. Covalent bond crosslinking of protein and lipid subcellular elements appears to underlie t he formation of polymerized aggregates of neurofilaments, other structural proteins and lipofuscin. The use of certain compounds may compete with cellular protein and lipid amine groups for reaction with disease-induced carbonyl-containing aliphatic and aromatic hydrocarbons. Such derivatized pharmacological agents can then be excreted by the kidneys, thus removing the toxic agent(s). The presence of an acid functional group on the agent used facilitates kidney recognition and removal. Another application of the prese nt invention includes the oral use of non-absorbable polyamine agents such as chitosan to covalently bind and sequester potentially toxic carbonyl compound present in the diet. Veterinary, food processing and cosmetic applications of the present invention are also described.
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