发明名称 |
TADG-15: an extracellular serine protease overexpressed in carcinomas |
摘要 |
The present invention provides DNA encoding a TADG-15 protein as well as a TADG-15 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell. The present invention further provides for methods of inhibiting TADG-15 expression and/or protease activity, methods of detecting TADG-15 mRNA and/or protein and methods of screening for TADG-15 inhibitors. Additionally, the present invention provides for cell-specific targeting via TADG-15 and methods of vaccinating an individual against TADG-15. The methods described are useful in the diagnosis, treatment and prevention of cancer, particularly breast and ovarian cancer.
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申请公布号 |
US2004086910(A1) |
申请公布日期 |
2004.05.06 |
申请号 |
US20030600187 |
申请日期 |
2003.06.20 |
申请人 |
O'BRIEN TIMOTHY J.;TANIMOTO HIROTOSHI |
发明人 |
O'BRIEN TIMOTHY J.;TANIMOTO HIROTOSHI |
分类号 |
A61K39/00;C12N9/64;C12Q1/68;(IPC1-7):C12Q1/68;G01N33/574;C07H21/04;C07K14/47 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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