发明名称 |
USE OF CHIMERIC NUCLEASES TO STIMULATE GENE TARGETING |
摘要 |
Gene targeting is a technique to introduce genetic change into one or more specific locations in the genome of a cell. For example, gene targeting can introduce genetic change by modifying, repairing, attenuating or inactivatin g a target gene or other chromosomal DNA. In one aspect, this disclosure relat es to methods and compositions for gene targeting with high efficiency in a cel l. This disclosure also relates to methods of treating or preventing a genetic disease in an individual in need thereof. Further disclosed are chimeric nucleases and vectors encoding chimeric nucleases. |
申请公布号 |
CA2497913(A1) |
申请公布日期 |
2004.05.06 |
申请号 |
CA20032497913 |
申请日期 |
2003.09.05 |
申请人 |
CALIFORNIA INSTITUTE OF TECHNOLOGY |
发明人 |
PORTEUS, MATTHEW;BALTIMORE, DAVID |
分类号 |
A61K48/00;C07H21/04;C12N9/22;C12N15/90;C12Q1/68 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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