A PAIR OF POLYPEPTIDES WITH SPECIFIC AND STRONG INTERACTION

摘要

The present invention relates to non-natural polypeptides selected from a pair of polypeptides which can bind to one another in the presence of high salt. Furthermore, the invention relates to nucleic acidc encoding these polypeptides, an affinity matrix comprising the non-natural polypeptides of the invention and a solid support, and a kit comprising an affinity matrix of the invention and a container. In addition, the invention relates to the use of a first polypeptide of the invention for the detection of a second polypeptide of the invention and also the use of a peptide derived from Dsllp and a peptide derived from 8-COP for the dimerization of polypeptides. Finally, the invention provides a method for the purification of a polypeptide of the invention.