发明名称 |
REPEAT SEQUENCES OF THE CA125 GENE AND THEIR USE FOR DIAGNOSTIC INTERVENTIONS |
摘要 |
<p>The CA125 gene has been cloned. The CA125 molecule comprises three major domains: an extracellular amino terminal domain; a large multiple repeat domain; and a carboxy terminal domain which includes a transmembrane anchor with a short cytoplasmic domain. Additionally, an amino terminal extension is present. The molecular structure is dominated by a repeat domain comprising more than sixty 156-amino-acid repeat units The repeat units encompass an interactive disulfide bridged C-enclosure and the site of OC125 and M11 binding. The CA125 molecule is anchored at its carboxy terminal through a transmembrane domain and a short cytoplasmic tail. The structure has potential for use as a new gold standard for detecting the CA125 antigen, and can provide a basis for the development of a vaccine useful for the treatment of ovarian cancer and other carcinomas where CA125 is elevated.</p> |
申请公布号 |
EP1414477(A2) |
申请公布日期 |
2004.05.06 |
申请号 |
EP20020723852 |
申请日期 |
2002.04.12 |
申请人 |
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS |
发明人 |
O'BRIEN, TIMOTHY;BEARD, JOHN;UNDERWOOD, LOWELL |
分类号 |
C07K14/47;G01N33/574;A61K31/7088;A61K38/00;A61K38/17;A61K39/00;A61K48/00;A61P35/00;C07K14/705;C07K16/28;C07K16/30;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12P21/02;C12Q1/68;(IPC1-7):A61K38/00;C07K1/00;C07K14/00;C07K17/00;A61K31/07 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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