Transdermal and topical administration of local anesthetic agents using basic enhancers

摘要

Compositions and transdermal systems are provided for enhancing the permeability of skin or mucosal tissue to topical or transdermal application of local anesthetic agents. The compositions and systems include a base in order to increase the flux of the agent through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. The permeation enhancer can be an inorganic or organic base. Methods of use are also described.