| 发明名称 |
ANTISENSE MODULATION OF ACYL COENZYME A CHOLESTEROL ACYLTRANSFERASE-1 EXPRESSION |
| 摘要 |
<p>Antisense compounds, compositions and methods are provided for modulating the expression of acyl coenzyme A cholesterol acyltransferase-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding acyl coenzyme A cholesterol acyltransferase-1. Methods of using these compounds for modulation of acyl coenzyme A cholesterol acyltransferase-1 expression and for treatment of diseases associated with expression of acyl coenzyme A cholesterol acyltransferase-1 are provided.</p> |
| 申请公布号 |
EP1414999(A1) |
申请公布日期 |
2004.05.06 |
| 申请号 |
EP20020763292 |
申请日期 |
2002.07.17 |
| 申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
CROOKE, ROSANNE, M.;GRAHAM, MARK, J.;LEMONIDIS TARBET, KRISTINA M. |
| 分类号 |
A61K38/00;C12N15/113;(IPC1-7):C12N15/54;C12N9/10;A61K31/711;A61K31/712;C12N15/11 |
主分类号 |
A61K38/00 |
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