| 摘要 |
Compounds of formula (I) in free or salt form, where Ar<1 >is phenyl substituted by one or more substituents selected from halogen, cyano, nitro, and C1-C8-alkyl optionally substituted by cyano or halogen, Ar<2 >is phenyl optionally which is unsubstituted or substituted by one or more substituents selected from halogen, cyano, hydroxy, nitro, C1-C8-alkyl, C1-C8-haloalkyl, C1-C8-alkoxy or C1-C8-alkoxycarbonyl, R<1 >is C1-C8-alkyl substituted by hydroxy, C1-C8-alkoxy, acyloxy, -N(R<2>)R<3>, halogen, carboxy, C1-C8-alkoxycarbonyl, phenyl-C1-C8-alkoxycarbonyl, -CON(R<4>)R<5 >or by a monovalent cyclic organic group, R<2 >and R?3 <custom-character file="US20040087621A1-20040506-P00900.TIF" wi="20" he="20" id="custom-character-00001"/> are each independently hydrogen or C1-C8-alkyl, or R<2 >is hydrogen and R<3 >is acyl or SO2R<6>, or R<2 >and R<3 >together with the nitrogen atom to which they are attached denote a 5- or 6-membered heterocyclic group, R<4 >and R<5 >are each independently hydrogen, C1-C8-alkyl optionally substituted by hydroxy or phenyl, or phenyl optionally substituted by C1-C8-alkyl, halogen, cyano or C1-C8-alkoxy, or R<4 >and R<5 >together with the nitrogen atom to which they are attached denote a 5- or 6-membered heterocyclic group, R?6 <custom-character file="US20040087621A1-20040506-P00900.TIF" wi="20" he="20" id="custom-character-00002"/> is C1-C8-alkyl, C1-C8-haloalkyl, or phenyl optionally substituted by C1-C8-alkyl, and n is 1, 2, 3 or 4. The compounds are useful as pharmaceuticals.
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