| 发明名称 |
Therapeutic agents comprising pro-apoptotic proteins |
| 摘要 |
The present invention relates to targeted killing of a cell utilizing a chimeric polypeptide comprising a cell-specific targeting moiety and a signal transduction pathway factor. In a preferred embodiment, the signal transduction pathway factor is an apoptosis-inducing factor, such as granzyme B, granzyme A, or Bax. |
| 申请公布号 |
EP1414471(A2) |
申请公布日期 |
2004.05.06 |
| 申请号 |
EP20020763328 |
申请日期 |
2002.07.17 |
| 申请人 |
RESEARCH DEVELOPMENT FOUNDATION |
发明人 |
ROSENBLUM, MICHAEL, G.;LIU, YUYING |
| 分类号 |
C12N15/09;C12N15/62;A61K38/00;A61K38/18;A61K38/48;A61K39/395;A61K45/00;A61K47/44;A61K47/48;A61K48/00;A61P1/04;A61P3/10;A61P9/10;A61P19/02;A61P27/02;A61P35/00;A61P35/04;A61P43/00;C07H21/04;C07K14/47;C07K14/475;C07K14/52;C07K14/575;C07K16/18;C07K16/22;C07K16/40;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/06;C12N5/10;C12N5/24;C12N7/00;C12N9/64;C12N15/12;C12P21/02;(IPC1-7):A61K31/70;C12P19/34 |
主分类号 |
C12N15/09 |
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