发明名称 |
Antisense compounds, methods and compositions for treating MMP-12 related inflammatory disorders |
摘要 |
The present invention relates antisense oligonucleotide compounds for use in modulating the function of nucleic acid molecules encoding mammalian MMP-12. More specifically, the invention provides compounds of 8 to 50 nucleobases in length capable of specifically hybridising with nucleic acid molecules encoding MMP-12 and thereby inhibiting the expression of the MMP-12 protein product, as well as pharmaceutical compositions thereof and methods of its use.
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申请公布号 |
US2004087533(A1) |
申请公布日期 |
2004.05.06 |
申请号 |
US20030619906 |
申请日期 |
2003.07.16 |
申请人 |
DIECKMANN ANDREAS;LOFBERG ROBERT;VON STEIN OLIVER;VON STEIN PETRA;GOOD LIAM |
发明人 |
DIECKMANN ANDREAS;LOFBERG ROBERT;VON STEIN OLIVER;VON STEIN PETRA;GOOD LIAM |
分类号 |
A61K38/00;C12N;C12N15/113;(IPC1-7):A61K48/00;C07H21/04 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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