发明名称 |
Superior molecular vaccine linking the translocation domain of a bacterial toxin to an antigen |
摘要 |
Nucleic acids encoding a chimeric or fusion polypeptide which polypeptide comprises a first domain comprising a translocation polypeptide; and a second domain comprising at least one antigenic peptide are disclosed. The preferred translocation polypeptide is a bacterial toxin translocation polypeptide, such as domain II of Pseudomonas aeruginosa exotoxin A (ETA(dII)). Such nucleic acids, expression vectors thereof, and cells expressing these vectors are used as vaccine compositions in a method for enhancing an antigen specific immune response, a method of increasing the numbers of CD8<+> CTLs specific for a selected desired antigen in a subject, or a method of inhibiting the growth of a tumor in a subject.
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申请公布号 |
US2004086845(A1) |
申请公布日期 |
2004.05.06 |
申请号 |
US20020115440 |
申请日期 |
2002.04.04 |
申请人 |
WU TZYY-CHOOU;HUNG CHIEN-FU |
发明人 |
WU TZYY-CHOOU;HUNG CHIEN-FU |
分类号 |
A61K38/00;A61K39/00;A61K48/00;C07K14/025;C07K14/21;C07K14/35;C07K14/475;C07K14/535;(IPC1-7):C12Q1/70;C12Q1/68;G01N33/554;G01N33/569;C07H21/04;C07K14/005;C07K14/195;C07K16/46 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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