Cyr61 as a target for treatment and diagnosis of breast cancer

摘要

The present invention contemplates methods of preventing or inhibiting breast cancer cell proliferation, compounds and compositions that interfere with or block sex steroid or growth factor binding to and induction of the Cyr61 gene and methods of screening ligands that regulate Cyr61 protein expression. The present invention further contemplates compounds that block Cyr61 activity. The invention further relates to methods of diagnosing and staging patients with cancers associated with an upregulation of Cyr61 expression. Assay methods and kits are also disclosed.