发明名称 |
ANTISENSE MODULATION OF ACYL COA CHOLESTEROL ACYLTRANSFERASE-2 EXPRESSION |
摘要 |
<p>Antisense compounds, compositions and methods are provided for modulating the expression of acyl CoA cholesterol acyltransferase-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding acyl CoA cholesterol acyltransferase-2. Methods of using these compounds for modulation of acyl CoA cholesterol acyltransferase-2 expression and for treatment of diseases associated with expression of acyl CoA cholesterol acyltransferase-2 are provided.</p> |
申请公布号 |
EP1414842(A2) |
申请公布日期 |
2004.05.06 |
申请号 |
EP20020752413 |
申请日期 |
2002.07.15 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
CROOKE, ROSANNE, M.;GRAHAM, MARK, J.;LEMONIDIS TARBET ,KRISTINA, M. |
分类号 |
A61K38/00;C12N15/113;(IPC1-7):C07H21/04;C12N5/00;C12Q1/68 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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