发明名称 |
PROCESS FOR PRODUCING OPTICALLY ACTIVE 2-ALKOXY-1-(TRIFLUOROMETHYL-SUBSTITUTED PHENYL)ETHANOL DERIVATIVES |
摘要 |
A process for producing an optically active 2-alkoxy-1-(trifluoromethyl-substituted phenyl)ethanol derivative represented by the formula 5: where R2 represents a C1-C6 lower alkyl group, n represents 1 or 2 and * represents a chiral carbon, includes the steps of (a) reducing an optically active, hydroxyl-protective, trifluoromethyl-substituted mandelate represented by the formula 1, by a hydride reducing agent, into an optically active, hydroxyl-protective 2-hydroxy-1-(trifluoromethyl-substituted phenyl)ethanol represented by the formula 2; (b) reacting the hydroxyl-protective hydroxyethanol represented by the formula 2, with an alkylation agent represented by the formula 3, in the presence of a base, thereby producing an optically active, hydroxyl-protective 2-alkoxy-1-(trifluoromethyl-substituted phenyl)ethanol represented by the formula 4; and (c) deprotecting the hydroxyl-protective alkoxyethanol represented by the formula 4 into the alkoxyethanol derivative represented by the formula 5. |
申请公布号 |
WO2004037760(A2) |
申请公布日期 |
2004.05.06 |
申请号 |
WO2003JP13474 |
申请日期 |
2003.10.22 |
申请人 |
CENTRAL GLASS COMPANY, LIMITED;ISHII, AKIHIRO;KANAI, MASATOMI;KURIYAMA, YOKUSU;YASUMOTO, MANABU;INOMIYA, KENJIN;OOTSUKA, TAKASHI;UEDA, KOJI |
发明人 |
ISHII, AKIHIRO;KANAI, MASATOMI;KURIYAMA, YOKUSU;YASUMOTO, MANABU;INOMIYA, KENJIN;OOTSUKA, TAKASHI;UEDA, KOJI |
分类号 |
C07B53/00;C07B61/00;C07C41/26;C07C43/178;C07C59/56;C07C67/08;C07C69/732;C07D309/12 |
主分类号 |
C07B53/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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