| 摘要 |
The present invention relates to new anti-cancer compounds and in particular to new compounds for use in nuclide activation therapy, such as neutron captures therapy. Specifically this invention provides a conjugate having the general formula P-(L-NAT)n , wherein P represents a biocompatible polymer having a molecular weight of 5-6,000 kDa; NAT represents a nuclide activation therapy agent; L represents a linker moiety capable of linking the polymer to the neutron capture therapy agent; and n represents an integer from 1-1,000, with the proviso that the polymer does not contain a single- or double-stranded oligonucleotide, an enzyme, an enzyme substrate, biotin or a biotin analogue, and with the further proviso that the polymer is not an N-hydroxypropylmethacrylamide-methacrylate copolymer. |
