发明名称 |
Process for preparing cephalosporanic acid derivatives using beta-ketoacid derivatives |
摘要 |
A process for preparing cephalosporanic acid derivatives comprises the steps of enzymatically converting a 3-thiolated cephalosporin C compound of formula III:into a 3-thiolated-alpha-ketoadipyl-7-aminocephalosporanic acid derivative of formula IV:wherein R is a heterocyclic group comprising at least a nitrogen atom.Compounds of formula IV are used in the preparation of cephalosporin C antibiotics and derivatives thereof.
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申请公布号 |
US6730497(B2) |
申请公布日期 |
2004.05.04 |
申请号 |
US20020125458 |
申请日期 |
2002.04.19 |
申请人 |
BIOFERMA MURCIA S.A. |
发明人 |
SANCHEZ-FERRER ALVARO;LOPEZ-MAS JOSE ANICETO;GARCIA-CARMONA FRANCISCO |
分类号 |
C12P35/06;C07D498/04;C07D501/00;C07D501/04;C07D501/12;C07D501/14;C07D501/18;C07D501/36;(IPC1-7):C12P35/00 |
主分类号 |
C12P35/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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