发明名称 |
METHOD FOR STABILIZING BIOMOLECULES IN LIQUID FORMULATIONS. |
摘要 |
<p>The invention is directed to a stable formulation of a biologically active protein useful for aerosol delivery to the respiratory tract of a patient in need of treatment comprising: (a) a carrier liquid comprising from about 10 % to from about 100 % V/V water and from about 0 % to from about 90 % V/V of an organic liquid; (b) a biologically effective amount of a protein suspended or dissolved in a carrier liquid; and (c) a stabilizing effective amount of a derivatized carbohydrate stabilizing agent suspended or dissolved in said carrier liquid. The stable formulations of the invention may optionally contain about 0.1 % to about 5.0 % W/V of a pharmaceutically acceptable excipient.</p> |
申请公布号 |
MXPA03004883(A) |
申请公布日期 |
2004.05.04 |
申请号 |
MX2003PA04883 |
申请日期 |
2001.10.30 |
申请人 |
BATTELLE MEMORIAL INSTITUTE |
发明人 |
COWAN, SIU, MAN, L. |
分类号 |
A61K9/12;A61K9/00;A61K9/10;A61K9/72;A61K38/00;A61K38/22;A61K38/28;A61K38/43;A61K38/46;A61K47/10;A61K47/26;A61P5/50;A61P11/00;(IPC1-7):A61K38/28 |
主分类号 |
A61K9/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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