发明名称 |
Press coated, pulsatile drug delivery system suitable for oral administration |
摘要 |
A press-coated tablet suitable for oral administration, comprising an immediate-release compartment comprising a compressed blend of an active agent. The immediate-release compartment has a dissolution profile in which 10-75% of the active agent is dissolved within one hour and not less than 90% of the active agent is dissolved within 6 hours. The tablet further comprises an extended-release compartment with a dissolution profile in which 5-40% of the active agent is dissolved within one hour, 20-75% within three hours, 40-95% of the active agent within 6 hours, and not less than 60% of the active agent is dissolved within 8 hours. Additionally, the press-coated extended-release compartment substantially envelops the immediate-release compartment, and comprises a compressed blend of the active agent, a hydrophilic polymer and hydrophobic material. The tablet exhibits a first order release of the active agent interrupted by a pulsed delivery of the active agent.
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申请公布号 |
US6730321(B2) |
申请公布日期 |
2004.05.04 |
申请号 |
US20020122410 |
申请日期 |
2002.04.16 |
申请人 |
IMPAX PHARMACEUTICALS, INC. |
发明人 |
TING RICHARD;HSIAO CHARLES |
分类号 |
A61K9/22;A61K9/24;A61K9/30;A61K9/32;A61K9/36;A61K9/38;(IPC1-7):A61K9/24;A61K9/20;A61K9/28 |
主分类号 |
A61K9/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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