PRODUCTION OF A LIVE VACCINE DIRECTED AGAINST INFLUENZA VIRUSES

摘要

The invention relates to a novel method for producing an attenuated influenza virus, which is homologous to the epidemic wild type strain and which is used as a vaccine directed against the influenza virus. The virus loses its pathogenicity by modifying an influenza surface protein but does not lose its immunogenicity, and it can be used as a live vaccine for immunizing individuals, particularly children, older people and immune-deficient individuals.