Thrombin inhibitors comprising an aminoisoquinoline group

摘要

A compound of formula (I) and its a pharmaceutically acceptable salt is disclosed, wherein: R1 is cyclopentyl, cyclohexil or branched (3-4C) alkyl; R2 is cyclohexyl or phenyl; R3 is H or methyl; and A is an unsubstituted saturated 4, 5 or 6-membered ring; or thereof. The compounds of formula (I) have anticoagulant activity and can be used in treating or preventing thrombin-mediated and thrombin-associated diseases.