Pharmaceutical dosage forms for controlled release producing at least a timed pulse

摘要

Disclosed are delayed release coated cores that produce at lease a timed pulse release or a stepped release profile comprising an active substance in their core and a polymer coating comprising at least one or more ammonio methacrylate copolymer, characterised in that the core comprises at least one or more surfactants, one of said surfactants being a means that diffuses into the polymer coating and at a given level provokes a sudden change in the coating's properties, said surfactants being cationic or zwitterionic; Also disclosed are monolithic or multiparticulate pharmaceutical dosage forms comprising such delayed release coated cores and to their method of manufacture.