BETA-AMYLOID SPECIFIC MONOCLONAL ANTIBODY AND METHOD FOR PREPARING THE SAME

摘要

PURPOSE: A beta-amyloid specific monoclonal antibody and a method for preparing the same are provided, thereby producing the function-improved antibody which strongly recognizes stable conformation of beta-amyloid by using a beta-amyloid-compound mixture as an antigen, so that the antibody can be useful for treatment of Alzheimer's disease caused by accumulation of beta-amyloid. CONSTITUTION: A monoclonal antibody specifically recognizes beta-amyloid, wherein the monoclonal antibody is prepared by using a mixture of beta-amyloid and a material which modifies the beta-amyloid into the stable conformation as an antigen. A method for preparing the beta-amyloid specific monoclonal antibody comprises the steps of: (1) preparing the mixture of beta-amyloid and the material which modifies the beta-amyloid into the stable conformation; and (2) immunizing the mixture as an antigen, wherein beta-amyloid comprises 1 to 42 amino acids or a portion thereof; and the material which modifies the beta-amyloid into the stable conformation is a compound represented by the formula(1), bio-molecule, or modified bio-molecule.