| 摘要 |
PURPOSE: Imidazoline compounds, a process for preparation thereof and pharmaceutical compositions containing the same compounds are provided. The compounds have antihyperglycaemic and antidiabetic properties or are capable of treating pathologies associated with imidazoline receptors. CONSTITUTION: The imidazoline compound selected from those of the formula(I), its enantiomers, diastereoisomers and tautomers thereof, and also addition salts thereof with a pharmaceutically acceptable acid or base are provided. In the formula(I), R1 is an optionally substituted heteroaryl group; R2 is an optionally substituted cycloalkyl group; R3 is a hydrogen atom or an alkyl group, and R4 and R5, which may be identical or different, are independently a hydrogen atom, a halogen atom or an alkyl, polyhaloalkyl, R10-C(X)-R11-, R10-Y-C(X)-R11-, R10-C(X)-Y-R11-, R10-Y-R11- or R10-S(O)n-R11- group, in which R10 is a hydrogen atom or an alkyl group; R11 is a bond, or an alkylene, alkenylene or alkynylene group; X is an oxygen atom, a sulphur atom, or an NR12 group in which R12 is a hydrogen atom or an alkyl group; Y is an oxygen atom, a sulphur atom, or an amino or alkylamino group; and n is an integer of from 1 to 2.
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