Benzodiazepine derivatives useful as metabotropic glutamate receptors

摘要

A benzodiazepine derivative or a pharmaceutically acceptable acid addition salt has the formula (I) wherein: X is a single bond or ethynediyl; when X is a single bond R1 is hydrogen, halogen, nitro, alkyl , haloalkyl, alkoxycarbonyl, optionally oxygen substituted cycloalkyl, optionally substituted benzoyl or phenyl, styrenyl, phenylethyl, naphthyl, biphenyl, benzofuranyl, or optionally substituted 5 or 6 membered heterocyclic ring; when X is ethynediyl R1 is hydrogen, optionally hydroxy substituted alkyl, haloalkyl, optionally substituted cycloalkyl or cycloalkenyl, alkenyl, optionally substituted phenyl, optionally substituted 5 or 6 membered heterocyclic ring or benzofuranyl; R3 is optionally substituted phenyl, pyridine, thiophenyl or thiazolyl; with the proviso when X is a single bond and R3 is pyridinyl, R1 is not hydrogen or methyl.