| 摘要 |
Substituted thioacetamides compounds of formula (I-A) and formula (II-A), processes for the preparation thereof and uses of the compositions in the treatment of diseases are disclosed, and wherein the variables are as defined in the specification. Compositions that include substituted thioacetamides of formula (I-A) or formula (II-A) are suitable for use in the treatment of diseases, including treatment of sleepiness, promotion of wakefulness, treatment of Parkinson's disease, cerebral ischemia, stroke, sleep apneas, eating disorders, stimulation of appetite and weight gain, treatment of attention deficit hyperactivity disorder ("ADHD"), enhancing function in disorders associated with hypofunctionality of the cerebral cortex, including, but not limited to, depression, schizophrenia, fatigue, in particular, fatigue associated with neurologic disease, such as multiple sclerosis, chronic fatigue syndrome, and improvement of cognitive dysfunction. |
