| 摘要 |
PURPOSE: Thionucleoside derivatives having anti-cancer activity and a pharmaceutical composition containing the same are provided. The compounds have selective activity to the adenosine A3 receptor, so that they can be useful for prevention and treatment of various cancers, inflammatory intestine disorders and inflammatory diseases. CONSTITUTION: Thionucleoside derivatives having anti-cancer activity represented by the formula(I) or pharmaceutically acceptable salts or isomers are provided, wherein X is sulfur or oxygen; R1 is hydrogen, C1 to C5 alkyl, benzyl, halobenzyl or phenylalkyl; R2 is hydrogen, halogen, alkoxy, alkenyl, alkynyl, alkylthio or thio; R3 and R3' are independently C1 to C5 hydroxyalkyl, alkoxycarbonyl or C1 to C5 alkylaminocarbonyl; and R4 is hydrogen or C1 to C5 alkyl. The pharmaceutical composition having adenosine A3 receptor selective activity contains the thionucleoside derivatives of the formula(I) as an effective component and pharmaceutically acceptable carriers.
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