| 摘要 |
<p>Method of obtaining anti diabetic agent of formula (7A) where in R=alkyl, aryl, heteroaryl, or trifluoromethyl as per the reaction scheme wherein the corresponding pyridine base of general formula (8A), where in Z is a leaving group other than halogen with p-nitro phenol (9) under basic conditions, followed by (a) catalytically reducing the nitro group in compound of general formula (10A) with hydrogen (b) diazotizing the amino group present in the organic residue (11A) (c) converting the diazotized residue into a derivative of 2-halopropionate of general formula (12A) following Meerwein arylation using acrylate ester (d) cyclizing the derivative of 2-halopropionate of formula (12A), with thiouriea (e) hydrolizing the resulting imine (13A), thus giving thiazolidinedione of general formula (7A) as an antidiabetic agent, in particular pioglitazone where R=ethyl in (7A).</p> |
